Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using pregabalin and each time you get a refill. Pregabalin is now off-patent and available as a generic medication. Regulatory agencies have approved generic versions of Pregabalin in various countries, including the FDA in the United States. Do not share pregabalin with other people, even if they have the same condition as you.
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- Avoid taking pregabalin extended-release tablets on an empty stomach.
- Do not use LYRICA for a condition for which it was not prescribed.
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On the other hand, other studies have shown that pregabalin provides faster and more significant relief of pain compared to gabapentin (10, 11). Regarding long-term safety data for the chronic use of pregabalin and gabapentin, in the case of pregabalin for the treatment of anxiety disorders, good tolerability has been observed with effective disease management (12). Both responders and non-responders showed low and similar discontinuation rates, with a good safety profile across a dosage range of 150–600 mg (12). Another study examined the effects of pregabalin over 2 years with doses above 300 mg for the treatment of patients with partial-onset epilepsy and found a higher discontinuation rate but good disease control (13). The most common but transient adverse events were dizziness, somnolence, headaches, and asthenia (13). In patients with chronic epilepsy treated for more than 3 years with 1,800 mg of gabapentin, 39% discontinued gabapentin owing to lack of efficacy (15).
Self-Medication And Untreated Conditions
Data were extracted from PubMed, Embase, Scopus, and the Cochrane Collaboration Library databases. The risk of bias was evaluated using the Cochrane Review Manager tool. Statistical analysis was performed using Review Manager 5.4.1 software, calculating effect sizes and conducting sensitivity analysis based on medication dosage. This rapid review has limitations due to its streamlined methods and search strategy. However, we comprehensively searched the literature and used standard criteria to assess the risk of bias and rate the quality of the evidence.
Five studies examined the effectiveness of pregabalin for treating central neuropathic pain including sciatica (radicular pain), poststroke pain and spinal cord injury-related pain. Outcome measures for pain included numerical rating scale (NRS), visual assessment scale (VAS), Short-Form McGill Pain Questionnaire visual assessment scale (SF-MPQ VAS) and SF-MPQ personal pain intensity (SF-MPQ PPI) index (see table 1 for full characteristics of included studies). The overall risk of bias in the included studies was moderate to high (figures 2 and 3).